Research streams
How ion channels are affected by mutations relevant to human disease. We study ion channels in cell lines or in mouse neurons to understand how mutations affect their role in excitability or neuronal plasticity.
Emergence of synaptic dysfunction in Alzheimer’s disease. We have used mouse models of Alzheimer’s disease to understand the synaptic modifications that correlate with the emergence of cognitive impairment, and we are investigating whether pharmacological intervention can rescue synapses and memory deficits early on in the process of neuronal deterioration.
Translating knowledge from mouse to human neurons. We are collaborating with various laboratories to establish whether the mechanisms by which amyloid beta and tau phosphorylation affect neurons in mice are also present in human neurons to focus on therapeutic intervention.
We thank the following funding bodies for supporting our work:
- Alzheimer’s Research UK
- Alzheimer’s Society
- Gerald Kerkut Trust
- Wessex Medical Research
- Gerald Kerkut Trust
- Rose Trees Trust
- CONACyT
- Royal society
