Research streams

Emergence of synaptic dysfunction in Alzheimer’s disease. We are using mouse models of Alzheimer’s disease to understand the synaptic modifications that correlate with the emergence of cognitive impairment, and we are investigating whether pharmacological intervention can rescue synapses and memory deficits early on in the process of neuronal deterioration.

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Translating knowledge from mouse to human neurons. We are collaborating with various laboratories to establish whether the mechanisms by which amyloid beta and tau phosphorylation affect neurons in mice are also present in human neurons to focus on therapeutic intervention.

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We thank the following funding bodies for supporting our current work: